Polysialic acid profiles of mice expressing variant allelic combinations of the polysialyltransferases ST8SiaII and ST8SiaIV.

@article{Galuska2006PolysialicAP,
  title={Polysialic acid profiles of mice expressing variant allelic combinations of the polysialyltransferases ST8SiaII and ST8SiaIV.},
  author={Sebastian P Galuska and Imke Oltmann-Norden and Hildegard Geyer and Birgit Weinhold and Klaus Kuchelmeister and Herbert Hildebrandt and Rita Gerardy-Schahn and Rudolf Geyer and Martina M{\"u}hlenhoff},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 42},
  pages={31605-15}
}
The post-translational modification of the neural cell adhesion molecule (NCAM) by polysialic acid (polySia) represents a remarkable example of dynamic modulation of homo- and heterophilic cell interactions by glycosylation. The synthesis of this unique carbohydrate polymer depends on the polysialyltransferases ST8SiaII and ST8SiaIV. Aiming to understand in more detail the contributions of ST8SiaII and ST8SiaIV to polySia biosynthesis in vivo, we used mutant mouse lines that differ in the… CONTINUE READING

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