Polysialic acid of the neural cell adhesion molecule distinguishes small cell lung carcinoma from carcinoids.

@article{Komminoth1991PolysialicAO,
  title={Polysialic acid of the neural cell adhesion molecule distinguishes small cell lung carcinoma from carcinoids.},
  author={Paul Komminoth and J{\"u}rgen Roth and Peter M. Lackie and Dieter Bitter-Suermann and P. U. Heitz},
  journal={The American journal of pathology},
  year={1991},
  volume={139 2},
  pages={297-304}
}
The neural cell adhesion molecule (NCAM) exists in various types of neuroendocrine cells and their tumors. A typical feature of NCAM is polysialic acid, of which the chain length is developmentally regulated. The authors have performed a comparative immunohistochemical study on small cell lung carcinomas and bronchial as well as gastrointestinal carcinoids with the monoclonal antibody (MAb) 735 reactive with the long-chain form of polysialic acid. The small cell lung carcinomas, irrespective of… CONTINUE READING

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