Polysialic acid glycomimetics promote myelination and functional recovery after peripheral nerve injury in mice.

@article{Mehanna2009PolysialicAG,
  title={Polysialic acid glycomimetics promote myelination and functional recovery after peripheral nerve injury in mice.},
  author={Ali Mehanna and Bibhudatta Mishra and Nina Kurschat and Christian Schulze and Shan Bian and Gabriele Loers and Andrey Irintchev and Melitta Schachner},
  journal={Brain : a journal of neurology},
  year={2009},
  volume={132 Pt 6},
  pages={
          1449-62
        }
}
alpha2,8 Polysialic acid (PSA) is a carbohydrate attached to the glycoprotein backbone of the neural cell adhesion molecule (NCAM) and implicated in nervous system development and repair. Here, we investigated whether PSA can improve functional recovery after peripheral nerve lesion in adult mice. We applied a functional PSA mimicking peptide or a control peptide in a polyethylene cuff used to surgically reconnect the severed stumps of the femoral nerve before it bifurcates into the motor and… CONTINUE READING

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