Polysialic acid and mucin type o-glycans on the neural cell adhesion molecule differentially regulate myoblast fusion.

@article{Suzuki2003PolysialicAA,
  title={Polysialic acid and mucin type o-glycans on the neural cell adhesion molecule differentially regulate myoblast fusion.},
  author={Misa Suzuki and Kiyohiko Angata and Jun Nakayama and Minoru Fukuda},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 49},
  pages={49459-68}
}
Polysialic acid attached to the neural cell adhesion molecule (NCAM) is thought to play a critical role in development. NCAM in muscle tissue contains a muscle-specific domain (MSD) to which mucin type O-glycans are attached. In the present study, using the C2C12 myoblast system, we show that NCAM containing MSD is increasingly expressed on the cell surface as myotubes form. Polysialic acid is primarily attached to N-glycans of NCAM, and polysialylated NCAM is expressed on the outer surface of… CONTINUE READING
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