Polysialic Acid: Versatile Modification of NCAM, SynCAM 1 and Neuropilin-2

  title={Polysialic Acid: Versatile Modification of NCAM, SynCAM 1 and Neuropilin-2},
  author={Martina M{\"u}hlenhoff and Manuela Rollenhagen and Sebastian Werneburg and Rita Gerardy-Schahn and Herbert Hildebrandt},
  journal={Neurochemical Research},
The glycan polysialic acid is well-known as a unique posttranslational modification of the neural cell adhesion molecule NCAM. Despite remarkable acceptor specificity, however, a few other proteins can be targets of polysialylation. Here, we recapitulate the biosynthesis of polysialic acid by the two polysialyltransferases ST8SIA2 and ST8SIA4 and highlight the increasing evidence that variation in the human ST8SIA2 gene is linked to schizophrenia and possibly other neuropsychiatric disorders… CONTINUE READING


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