Polysaccharides in Fungi. XXXIV. A polysaccharide from the fruiting bodies of Amanita muscaria and the antitumor activity of its carboxymethylated product.

@article{Kiho1994PolysaccharidesIF,
  title={Polysaccharides in Fungi. XXXIV. A polysaccharide from the fruiting bodies of Amanita muscaria and the antitumor activity of its carboxymethylated product.},
  author={Tadashi Kiho and Izumi Yoshida and Misaki Katsuragawa and M Sakushima and Shigeyuki Usui and Satoshi Ukai},
  journal={Biological & pharmaceutical bulletin},
  year={1994},
  volume={17 11},
  pages={
          1460-2
        }
}
A water-insoluble, alkali-soluble, glucan (AM-APP), [alpha]D +160 degrees in 0.4 M NaOH, was isolated from the alkaline extract of the fruiting bodies of Amanita muscaria. The results of chemical and spectroscopic investigations indicate that AM-APP is a linear (1 --> 3)-alpha-D-glucan with a molecular weigh estimated by gel chromatography of about 42000. Its carboxymethylated product (AM-APP-CM) showed potent antitumor activity against sarcoma 180 in mice, although the native polysaccharide… CONTINUE READING
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