Polysaccharides from Dioscorea batatas induce tumor necrosis factor-alpha secretion via Toll-like receptor 4-mediated protein kinase signaling pathways.

@article{Liu2008PolysaccharidesFD,
  title={Polysaccharides from Dioscorea batatas induce tumor necrosis factor-alpha secretion via Toll-like receptor 4-mediated protein kinase signaling pathways.},
  author={J -H. Liu and Feng-Ling Yang and Chun-ping Lu and Yu-liang Yang and C G Wen and Kuo-Feng Hua and Shih-Hsiung Wu},
  journal={Journal of agricultural and food chemistry},
  year={2008},
  volume={56 21},
  pages={9892-8}
}
The bioactive polysaccharides (named ZPF1) from yam ( Dioscorea batatas) were chemically determined, suggesting repeating beta-1,4-mannan as mainly having a feature of acetylation on C2-OH and C3-OH, around 28%. The ZPF1 participated in the stimulation of murine wild-type macrophages predominantly in tumor necrosis factor-alpha (TNFalpha). Toll-like receptor 4 is proved to be one of the cellular receptors in ZPF1-mediated TNFalpha secretion. Reactive oxygen species transmission and PI3-kinase… CONTINUE READING