Polysaccharide-based nucleic acid nanoformulations.

@article{Raemdonck2013PolysaccharidebasedNA,
  title={Polysaccharide-based nucleic acid nanoformulations.},
  author={Koen van Raemdonck and Thomas Frans Martens and Kevin Braeckmans and Jo Demeester and Stefaan C De Smedt},
  journal={Advanced drug delivery reviews},
  year={2013},
  volume={65 9},
  pages={
          1123-47
        }
}
Therapeutic application of nucleic acids requires their encapsulation in nanosized carriers that enable safe and efficient intracellular delivery. Before the desired site of action is reached, drug-loaded nanoparticles (nanomedicines) encounter numerous extra- and intracellular barriers. Judicious nanocarrier design is highly needed to stimulate nucleic acid delivery across these barriers and maximize the therapeutic benefit. Natural polysaccharides are widely used for biomedical and… CONTINUE READING
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