Polysaccharide Specific Monoclonal Antibodies Provide Passive Protection against Intranasal Challenge with Burkholderia pseudomallei

@inproceedings{AuCoin2012PolysaccharideSM,
  title={Polysaccharide Specific Monoclonal Antibodies Provide Passive Protection against Intranasal Challenge with Burkholderia pseudomallei},
  author={David P AuCoin and Dana E. Reed and Nicole L. Marlenee and Richard A. Bowen and Peter Thorkildson and Barbara M. Judy and Alfredo G Torres and Thomas R. Kozel},
  booktitle={PloS one},
  year={2012}
}
Burkholderia pseudomallei is a Gram-negative bacillus that is the causative agent of melioidosis. The bacterium is inherently resistant to many antibiotics and mortality rates remain high in endemic areas. The lipopolysaccharide (LPS) and capsular polysaccharide (CPS) are two surface-associated antigens that contribute to pathogenesis. We previously developed two monoclonal antibodies (mAbs) specific to the CPS and LPS; the CPS mAb was shown to identify antigen in serum and urine from… CONTINUE READING
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