Polyreactivity increases the apparent affinity of anti-HIV antibodies by heteroligation

  title={Polyreactivity increases the apparent affinity of anti-HIV antibodies by heteroligation},
  author={Hugo Mouquet and Johannes F. Scheid and Markus Josef Zoller and Michelle Krogsgaard and Rene G. Ott and Shetha A. Shukair and Maxim N. Artyomov and John Pietzsch and Mark Connors and Florencia Pereyra and Bruce D. Walker and David D. Ho and Patrick C. Wilson and Michael S. Seaman and Herman N. Eisen and Arup K. Chakraborty and Thomas J Hope and Jeffrey V Ravetch and Hedda Wardemann and Michel C. Nussenzweig},
During immune responses, antibodies are selected for their ability to bind to foreign antigens with high affinity, in part by their ability to undergo homotypic bivalent binding. However, this type of binding is not always possible. For example, the small number of gp140 glycoprotein spikes displayed on the surface of the human immunodeficiency virus (HIV) disfavours homotypic bivalent antibody binding. Here we show that during the human antibody response to HIV, somatic mutations that increase… CONTINUE READING
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