Polyreactive antigen‐binding B cells are the predominant cell type in the newborn B cell repertoire

@article{Chen1998PolyreactiveAB,
  title={Polyreactive antigen‐binding B cells are the predominant cell type in the newborn B cell repertoire},
  author={Z J Chen and Carl J. Wheeler and W. Shi and Ava J. Wu and Cheryl H Yarboro and Mary Gallagher and Abner Louis Notkins},
  journal={European Journal of Immunology},
  year={1998},
  volume={28}
}
Polyreactive antibodies bind to a variety of different self and non‐self antigens. The B cells that make these antibodies express the polyreactive Ig receptor on their surface. To determine the frequency of polyreactive antigen‐binding B cells in peripheral blood, we incubated two different antigens, one (insulin) labeled with fluorescein isothiocyanate and the other (β‐galactosidase) with phycoerythrin, with peripheral B cells. The percentage of cells that bound these antigens was determined… 
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TLDR
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TLDR
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TLDR
It is concluded that the polyreactive antibodies in the natural antibody repertoire contribute in a major way to the clearance of cells made apoptotic by a variety of natural and infectious processes.
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TLDR
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TLDR
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References

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TLDR
It is concluded that polyreactive antigen‐binding B cells have properties that are consistent with the ability to induce immunological tolerance.
Antigen‐binding B cells and polyreactive antibodies
TLDR
It is concluded that cells capable of binding a variety of different antigens can makepolyreactive antibodies and that antigen binding is a good marker for identifying polyreactive antibody‐producing cells.
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TLDR
It is concluded that the Leu-1+ lymphocytes represent a major subset of the normal human B cell repertoire and include the B cells capable of making autoantibodies similar to those found in systemic lupus erythematosus and rheumatoid arthritis.
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TLDR
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TLDR
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Polyreactive antibodies (Abs) constitute a major proportion of the early Ab repertoire and are an important component of the natural defense mechanisms against infections. They are primarily
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TLDR
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TLDR
Sequencing of the genes encoding the H chain CDR3 (D segments) revealed that all three low-affinity polyreactive RF mAb displayed a much longer D segment than their high-Affinity monoreactive counterparts, raising the possibility that a long D segment may be one of the factors involved in antibody polyreactivity.
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