Acute polyradiuloneuritis is acute inflammatory demyelinizing polyneuropathy, with still unknown cause, and which main pathophysiological disorder is degeneration of axons which affects peripheral nerves. Most frequently it occurs as acute, several days or weeks after viral, respiratory or gastrointestinal infections. Survival rate is in the world between - of cases. The goal of the research is to determine by retrospective study number of cases of acute polyradiculoneuritis during the war in the Sarajevo under the siege and their outcome. In this paper we have analyzed total number of acute polyradiculoneuritis cases within the period since April until April , when the city of Sarajevo was completely under siege. Diagnostic criteria’s besides anamnesis was detailed neurological exam, blood tests, analysis of the cerebrospinal liquor, EMG, ECG and cardiac tests. Within the above mentioned period there was cases of polyradiculoneuritis, male and females, age between - years. Motor weakness and parestesias was most dominant in clinical image. Number of cases increased during the years and it was greatest during . Previous infections were noted in cases, and of those respiratory, and one case of gastrointestinal. Proteinorahia in liquor was found among cases ( during first and during the second week of illness). Pathological EMG was found in cases. Milder form of illness had patients, while patients had more severe form. In total patients survived, of them without consequences, with milder and with more severe consequences while in cases there was a lethal outcome.