Polypyrrole Composite Nanoparticles with Morphology-Dependent Photothermal Effect and Immunological Responses.

@article{Tian2016PolypyrroleCN,
  title={Polypyrrole Composite Nanoparticles with Morphology-Dependent Photothermal Effect and Immunological Responses.},
  author={Yefei Tian and Jianping Zhang and Shiwei Tang and Lei Zhou and Wuli Yang},
  journal={Small},
  year={2016},
  volume={12 6},
  pages={
          721-6
        }
}
Polypyrrole composite nanoparticles with controlled shape are synthesized, which exhibit a morphology-dependent photothermal effect: the raspberry-like composite nanoparticles have a much better photothermal effect than the spherical ones, and the immune responses to the nanocomposites are also dependent on their morphology. The outstanding performance of the nanocomposites promises their potential application in photothermal therapy and immunotherapy of cancer. 

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References

SHOWING 1-10 OF 35 REFERENCES
Uniform polypyrrole nanoparticles with high photothermal conversion efficiency for photothermal ablation of cancer cells.
TLDR
Uniform polypyrrole nanoparticles are fabricated from a facile one-step aqueous dispersion polymerization and can be used as a novel promising photothermal ablation coupling agent for targeted treatment of cancer.
Multifunctional polypyrrole@Fe(3)O(4) nanoparticles for dual-modal imaging and in vivo photothermal cancer therapy.
TLDR
The obtained PPY@Fe(3)O(4)composite nanoparticles exhibit good photostability and biocompatibility, and they can be used as multifunctional probes for MRI, thermal imaging, and photothermal ablation of cancer cells.
Biodegradable gold nanovesicles with an ultrastrong plasmonic coupling effect for photoacoustic imaging and photothermal therapy.
TLDR
A novel theranostic platform based on biodegradable plasmonic gold nanovesicles for photoacoustic (PA) imaging and PTT with improved clearance of the dissociated particles after the completion of PTT is reported.
Synthesis of PEGylated gold nanostars and bipyramids for intracellular uptake.
TLDR
In this paper, a complete study of P EGylated gold nanostars and PEGylated bipyramidal-like nanostructures is presented and it is shown that the biocompatible gold nanoparticles were easily internalized and most of them localized within the cells.
Immunological responses triggered by photothermal therapy with carbon nanotubes in combination with anti-CTLA-4 therapy to inhibit cancer metastasis.
Photothermal ablation of primary tumors with single-walled carbon nanotubes is demonstrated to be able to trigger significant adaptive immune responses, which are not observed if tumors are removed
Facile Surface Functionalization of Hydrophobic Magnetic Nanoparticles
TLDR
A facile, high efficiency, single-phase and low-cost method to convert hydrophobic magnetic nanoparticles (MNPs) to an aqueous phase using tetrahydrofuran, NaOH and 3,4-dihydroxyhydrocinnamic acid without any complicated organic synthesis is developed.
Rationally designed gibbous stimuli-responsive colloidal nanoparticles.
TLDR
Using a simple free radical polymerization process, copolymer nanoparticles are synthesized with controlled stimuli-responsive phase-separated gibbosities and may offer a number of possibilities for controllable design of ordered heterogeneousCopolymer morphologies for a variety of applications.
Near infrared laser-induced targeted cancer therapy using thermoresponsive polymer encapsulated gold nanorods.
TLDR
The NIR laser-induced targeted cancer thermo-chemotherapy without using targeting ligands represents a novel targeted anticancer strategy with facile control and practical efficacy.
Gold nanocages: synthesis, properties, and applications.
TLDR
It is found that changing the amount of metal precursor added to the suspension of Ag nanocubes is a simple means of tuning both the composition and the localized surface plasmon resonance (LSPR) of the metal nanocages.
...
1
2
3
4
...