Polypyrimidine tract-binding protein regulates the cell cycle through IRES-dependent translation of CDK11(p58) in mouse embryonic stem cells.

@article{Ohno2011PolypyrimidineTP,
  title={Polypyrimidine tract-binding protein regulates the cell cycle through IRES-dependent translation of CDK11(p58) in mouse embryonic stem cells.},
  author={Satona Ohno and Masaki Shibayama and Mitsuharu Sato and Akinori Tokunaga and Nobuaki Yoshida},
  journal={Cell cycle},
  year={2011},
  volume={10 21},
  pages={3706-13}
}
Polypyrimidine tract-binding protein (PTB/PTBP1/hnRNP I) is a member of the heterogeneous nuclear ribonucleoprotein family that binds specifically to pyrimidine-rich sequences of RNAs. Although PTB is a multifunctional protein involved in RNA processing and internal ribosome entry site (IRES)-dependent translation, the role of PTB in early mouse development… CONTINUE READING