Polypyrimidine tract-binding protein is involved in regulation of albumin synthesis in response to food intake.

  title={Polypyrimidine tract-binding protein is involved in regulation of albumin synthesis in response to food intake.},
  author={Masashi Kuwahata and Yasuko Kuramoto and Yukiko Sawai and Saki Amano and Yuka Tomoe and Hiroko Segawa and Sawako Tatsumi and Mikiko Ito and Yukiko Kobayashi and Yasuhiro Kido and Tatsuzo Oka and Ken-Ichi Miyamoto},
  journal={Journal of nutritional science and vitaminology},
  volume={54 2},
Our recent study demonstrates that polypyrimidine tract-binding protein (PTB), which is a sequence specific RNA-binding protein, attenuates albumin synthesis in a cell-free translation system. In this study, the effects of food intake on regulation of albumin synthesis through binding of PTB to albumin messenger RNA (mRNA) were investigated. Rats were divided into 1 of 3 groups: fed; fasted for 36 h; or fasted for 36 h and then refed for 24 h. No significant differences in albumin mRNA levels… CONTINUE READING

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