Polypurine sequences within a downstream exon function as a splicing enhancer.

@article{Tanaka1994PolypurineSW,
  title={Polypurine sequences within a downstream exon function as a splicing enhancer.},
  author={Keiji Tanaka and A Watakabe and Yoshiro Shimura},
  journal={Molecular and cellular biology},
  year={1994},
  volume={14 2},
  pages={1347-54}
}
We have previously shown that a purine-rich sequence located within exon M2 of the mouse immunoglobulin mu gene functions as a splicing enhancer, as judged by its ability to stimulate splicing of a distant upstream intron. This sequence element has been designated ERS (exon recognition sequence). In this study, we investigated the stimulatory effects of various ERS-like sequences, using the in vitro splicing system with HeLa cell nuclear extracts. Here, we show that purine-rich sequences of… CONTINUE READING
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