Polypurine reverse Hoogsteen hairpins as a gene therapy tool: in vitro development and in vivo validation

@inproceedings{Gallego2015PolypurineRH,
  title={Polypurine reverse Hoogsteen hairpins as a gene therapy tool: in vitro development and in vivo validation},
  author={Laura Rodr{\'i}guez Gallego},
  year={2015}
}
The work presented in this thesis is focused on the study of Polypurine Reverse Hoogsteen hairpins (PPRHs) as gene silencing tools. PPRHs are double-stranded DNA molecules formed by tvvo anti parallel homopurine domains linked by a 5-thymidine loop, which form intramolecular reverse Hoogsteen bonds. Previously in our lab it was demonstrated that these molecules bind to their pyrimidine target sequence, and induce the displacement of the purine strand, at settings similar to physiological… CONTINUE READING

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