Polypurine reverse Hoogsteen hairpins as a gene therapy tool: in vitro development and in vivo validation

@inproceedings{Gallego2015PolypurineRH,
  title={Polypurine reverse Hoogsteen hairpins as a gene therapy tool: in vitro development and in vivo validation},
  author={Laura Rodr{\'i}guez Gallego},
  year={2015}
}
As a new approach for gene therapy, we recently developed a new type of molecule called polypurine reverse Hoogsteen hairpins (PPRHs). We decided to explore the in vitro and in vivo effect of PPRHs in cancer choosing survivin as a target since it is involved in apoptosis, mitosis and angiogenesis, and overexpressed in different tumors. We designed four PPRHs against the survivin gene, one of them directed against the template strand and three against different regions of the coding strand… CONTINUE READING

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