Polypurine-repeat-containing RNAs: a novel class of long non-coding RNA in mammalian cells

  title={Polypurine-repeat-containing RNAs: a novel class of long non-coding RNA in mammalian cells},
  author={Ruiping Zheng and Zhen Shen and Vidisha Tripathi and Zhenyu Xuan and Susan M. Freier and C. Frank Bennett and Supriya G Prasanth and Kannanganattu V. Prasanth},
  journal={Journal of Cell Science},
  pages={3734 - 3744}
In higher eukaryotic cells, long non-protein-coding RNAs (lncRNAs) have been implicated in a wide array of cellular functions. Cell- or tissue-specific expression of lncRNA genes encoded in the mammalian genome is thought to contribute to the complex gene networks needed to regulate cellular function. Here, we have identified a novel species of polypurine triplet repeat-rich lncRNAs, designated as GAA repeat-containing RNAs (GRC-RNAs), that localize to numerous punctate foci in the mammalian… 

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