Polyps wrap mast cells and Treg within tumorigenic tentacles.

  title={Polyps wrap mast cells and Treg within tumorigenic tentacles.},
  author={Mario P Colombo and Silvia Piconese},
  journal={Cancer research},
  volume={69 14},
Gounaris and colleagues describe a previously unrecognized cross-talk between mast cells and Treg in colon adenomatous polyposis (Gounaris et al., Cancer Res 2009;69:5490-7). Adoptively transferred Treg suppress the focal mastocytosis that fosters tumor initiation and progression. In contrast, endogenous Treg, which abundantly infiltrate polyps, show proinflammatory activity under unknown microenvironmental cues that promote mast cell differentiation and expansion. Compartmentalized Treg… CONTINUE READING