Polyprotein context regulates the activity of poliovirus 2CATPase bound to bilayer nanodiscs.


Positive-strand RNA viruses generally replicate in large membrane-associated complexes. For poliovirus, these replication complexes are anchored to the membrane via the viral 2B, 2C, and 3A proteins. 2C is an AAA+ family ATPase that plays a key role in host cell membrane rearrangement, is a putative helicase, and is implicated in virion assembly and… (More)
DOI: 10.1128/JVI.03491-12


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