Polyprenyl Immunostimulant Treatment of Cats with Presumptive Non-Effusive Feline Infectious Peritonitis In a Field Study

@article{Legendre2017PolyprenylIT,
  title={Polyprenyl Immunostimulant Treatment of Cats with Presumptive Non-Effusive Feline Infectious Peritonitis In a Field Study},
  author={Alfred M. Legendre and Tanya Kuritz and Gina D. Galyon and Vivian M. Baylor and R. Eric Heidel},
  journal={Frontiers in Veterinary Science},
  year={2017},
  volume={4}
}
Feline infectious peritonitis (FIP) is a fatal disease with no clinically effective treatment. This field study evaluated treatment with Polyprenyl Immunostimulant (PI) in cats with the non-effusive form of FIP. Because immune suppression is a major component in the pathology of FIP, we hypothesized that treatment with an immune system stimulant would increase survival times of cats with dry FIP. Sixty cats, diagnosed with dry FIP by primary care and specialist veterinarians and meeting the… Expand
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References

SHOWING 1-10 OF 42 REFERENCES
Treatment of cats with feline infectious peritonitis
TLDR
It is suggested that these agents may benefit infected animals by restoring compromised immune function, thereby allowing the patient to control viral burden and recover from clinical signs, and a non-specific stimulation of the immune system may be contraindicated. Expand
Effect of Polyprenyl Immunostimulant on the survival times of three cats with the dry form of feline infectious peritonitis
TLDR
Three cats with dry form FIP were treated with Polyprenyl Immunostimulant and two of the three cats are still on treatment and are alive and well 2 years after diagnosis. Expand
Clinical and laboratory features of cats with feline infectious peritonitis – a retrospective study of 231 confirmed cases (2000–2010)
TLDR
The low prevalence of lymphopenia in cats without effusion suggests that this is not a useful parameter in non-effusive FIP, and potential changes in diagnostic criteria for FIP are evaluated. Expand
Effect of Feline Interferon‐Omega on the Survival Time and Quality of Life of Cats with Feline Infectious Peritonitis
TLDR
No effect of FeIFN‐ω on survival time or quality of life could be demonstrated in this study. Expand
Feline infectious peritonitis. ABCD guidelines on prevention and management
TLDR
The clinical picture of FIP is highly variable, depending on the distribution of the vasculitis and pyogranulomatous lesions, and there are no controlled studies to prove any beneficial effect of corticosteroids. Expand
An update on feline infectious peritonitis: Virology and immunopathogenesis
TLDR
After a half century, FIP remains one of the last important infections of cats for which there is no single diagnostic test, no vaccine and no definitive explanations for how virus and host interact to cause disease. Expand
Epidemiology of feline infectious peritonitis among cats examined at veterinary medical teaching hospitals.
TLDR
It is indicated that FIP continues to be a clinically important disease in North America and that sexually intact male cats may be at increased risk, and spayed females at reduced risk, for FIP. Expand
A review of feline infectious peritonitis virus infection: 1963–2008
  • N. Pedersen
  • Medicine
  • Journal of Feline Medicine & Surgery
  • 2009
TLDR
F eline infectious peritonitis (FIP) was first described as an ‘important disorder of cats’ by Holzworth in 1963 and a clinico-pathologic conference on this disorder was published in the following year. Expand
Clinicopathological findings and disease staging of feline infectious peritonitis: 51 cases from 2003 to 2009 in Taiwan
TLDR
The packed cell volume, bilirubin, AST, potassium, and sodium levels were established to predict disease staging and survival time and indicate that the cat can survive for at least 2 weeks, less than 2 weeks and less than 3 days, respectively. Expand
An outbreak of feline infectious peritonitis in a Taiwanese shelter: epidemiologic and molecular evidence for horizontal transmission of a novel type II feline coronavirus
Feline infectious peritonitis (FIP) is a fatal disease caused by feline coronavirus (FCoV) infection. FCoV can be divided into serotypes I and II. The virus that causes FIP (FIPV) is believed toExpand
...
1
2
3
4
5
...