Polyploidy induction as a consequence of topoisomerase inhibition. A flow cytometric assessment.

@article{Zucker1991PolyploidyIA,
  title={Polyploidy induction as a consequence of topoisomerase inhibition. A flow cytometric assessment.},
  author={Robert Martin Zucker and David J Adams and Kenneth W. Bair and Kenneth H. Elstein},
  journal={Biochemical pharmacology},
  year={1991},
  volume={42 11},
  pages={2199-208}
}
Following recovery from a 4-hr exposure to clinically achievable concentrations of the topoisomerase II inhibitors Adriamycin, teniposide, or amsacrine or the putative topoisomerase II inhibitor crisnatol, murine erythroleukemic cells remained viable for up to 48 hr, but did not proliferate. Cell cycle analysis after a 24-hr recovery revealed blocks in G2 (4N DNA) or greater than G2 (up to 8N DNA) polyploid stages. The relative percentages of cells in either stage was a function of drug… CONTINUE READING

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