Polyploidy and liver proliferation: Central role of insulin signaling

  title={Polyploidy and liver proliferation: Central role of insulin signaling},
  author={S. Celton-Morizur and G. Merlen and D. Couton and C. Desdouets},
  journal={Cell Cycle},
  pages={460 - 466}
  • S. Celton-Morizur, G. Merlen, +1 author C. Desdouets
  • Published 2010
  • Biology, Medicine
  • Cell Cycle
  • The formation of polyploid cells is part of the developmental program in several tissues. Polyploidy is a characteristic feature of mammalian hepatocytes and it is emerging that this process is an important mechanism of restricting liver growth. We previously demonstrated that during post-natal development, binucleated tetraploid hepatocytes arise due to a failure in cytokinesis. The genesis of such binucleated tetraploid cells is the crucial step for the establishment of liver polyploidization… CONTINUE READING
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