Polyploid tumour cells elicit paradiploid progeny through depolyploidizing divisions and regulated autophagic degradation

@article{Erenpreisa2011PolyploidTC,
  title={Polyploid tumour cells elicit paradiploid progeny through depolyploidizing divisions and regulated autophagic degradation},
  author={J. Erenpreisa and K. Salmiņa and A. Huna and E. Kosmacek and M. Cragg and F. Ianzini and A. P. Anisimov},
  journal={Cell Biology International},
  year={2011},
  volume={35}
}
‘Neosis’ describes the process whereby p53 function‐deficient tumour cells undergo self‐renewal after genotoxic damage apparently via senescing ETCs (endopolyploid tumour cells). We previously reported that autophagic digestion and extrusion of DNA occurs in ETC and subsequently revealed that self‐renewal transcription factors are also activated under these conditions. Here, we further studied this phenomenon in a range of cell lines after genotoxic damage induced by gamma irradiation, ETO… Expand
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