Polyplexes assembled from self-peptides and regulatory nucleic acids blunt toll-like receptor signaling to combat autoimmunity.

@article{Hess2017PolyplexesAF,
  title={Polyplexes assembled from self-peptides and regulatory nucleic acids blunt toll-like receptor signaling to combat autoimmunity.},
  author={Krystina L. Hess and James I. Andorko and Lisa H Tostanoski and Christopher M Jewell},
  journal={Biomaterials},
  year={2017},
  volume={118},
  pages={
          51-62
        }
}
Autoimmune diseases occur when the immune system incorrectly recognizes self-molecules as foreign; in the case of multiple sclerosis (MS), myelin is attacked. Intriguingly, new studies reveal toll-like receptors (TLRs), pathways usually involved in generating immune responses against pathogens, play a significant role in driving autoimmune disease in both humans and animal models. We reasoned polyplexes formed from myelin self-antigen and regulatory TLR antagonists might limit TLR signaling… CONTINUE READING
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