Polyplex-releasing microneedles for enhanced cutaneous delivery of DNA vaccine.

  title={Polyplex-releasing microneedles for enhanced cutaneous delivery of DNA vaccine.},
  author={Nak Won Kim and Min Sang Lee and Kyu Ri Kim and Jung Eun Lee and Kyuri Lee and Jong Sung Park and Yoh Matsumoto and D H Jo and Haeshin Lee and Doo Sung Lee and Ji Hoon Jeong},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
Microneedle (MN)-based DNA vaccines have many advantages over conventional vaccines administered by hypodermic needles. However, an efficient strategy for delivering DNA vaccines to intradermal cells has not yet been established. Here, we report a new approach for delivering polyplex-based DNA vaccines using MN arrays coated with a pH-responsive polyelectrolyte multilayer assembly (PMA). This approach enabled rapid release of polyplex upon application to the skin. In addition to the polyplex… CONTINUE READING
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