Polyplex exposure inhibits cell cycle, increases inflammatory response, and can cause protein expression without cell division.

Abstract

We sought to evaluate the relationship between cell division and protein expression when using commercial poly(ethylenimine) (PEI)-based polyplexes. The membrane dye PKH26 was used to assess cell division, and cyan fluorescent protein (CFP) was used to monitor protein expression. When analyzed at the whole population level, a greater number of cells divided… (More)
DOI: 10.1021/mp300470d

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