Polyphosphoinositide breakdown as the initiating reaction in receptor-stimulated inositol phospholipid metabolism.


All cell-surface receptors that bring about a rise in cytosol Ca2+ concentration upon stimulation appear also to provoke enhanced metabolism of inositol phospholipids. For many years, it has been thought that the initiating reaction in this response is phosphodiesterase-catalysed breakdown of phosphatidylinositol (PtdIns). However, recent experiments with… (More)


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