Polyphosphate: a link between platelets, coagulation and inflammation.

@article{Morrissey2012PolyphosphateAL,
  title={Polyphosphate: a link between platelets, coagulation and inflammation.},
  author={James H Morrissey},
  journal={International journal of hematology},
  year={2012},
  volume={95 4},
  pages={346-52}
}
Inorganic polyphosphate (polyP) is abundant in biological organisms. PolyP is a major component of dense granules of human platelets and is secreted upon platelet activation. Studies from our lab and others have shown that polyP is a potent modulator of the blood clotting cascade, acting as a pro-hemostatic, prothrombotic and proinflammatory agent depending on its polymer size and location. PolyP may represent at least one of the long-sought (patho)physiologic activators of the contact pathway… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 17 extracted citations

Similar Papers

Loading similar papers…