Polyphosphate: A Conserved Modifier of Amyloidogenic Processes.

  title={Polyphosphate: A Conserved Modifier of Amyloidogenic Processes.},
  author={Claudia M. Cremers and Daniela Knoefler and Stephanie N Gates and Nicholas Martin and Jan-Ulrik Dahl and Justine Lempart and Lihan Xie and Matthew R Chapman and V. A. Galvan and Daniel R Southworth and Ursula Jakob},
  journal={Molecular cell},
  volume={63 5},
Polyphosphate (polyP), a several billion-year-old biopolymer, is produced in every cell, tissue, and organism studied. Structurally extremely simple, polyP consists of long chains of covalently linked inorganic phosphate groups. We report here the surprising discovery that polyP shows a remarkable efficacy in accelerating amyloid fibril formation. We found that polyP serves as an effective nucleation source for various different amyloid proteins, ranging from bacterial CsgA to human α-synuclein… CONTINUE READING
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