Polyphenols prevent cell shedding from mouse mammary cancer spheroids and inhibit cancer cell invasion in confrontation cultures derived from embryonic stem cells.

@article{Gnther2007PolyphenolsPC,
  title={Polyphenols prevent cell shedding from mouse mammary cancer spheroids and inhibit cancer cell invasion in confrontation cultures derived from embryonic stem cells.},
  author={Sebastian G{\"u}nther and Carola Ruhe and Maria Gertrude Derikito and Gregor Boese and Heinrich Sauer and Maria Wartenberg},
  journal={Cancer letters},
  year={2007},
  volume={250 1},
  pages={25-35}
}
The prognosis of cancer disease is worsened upon shedding of tumor cells from the primary tumor, which escape to the blood stream and form metastases at distant sites within the body. Inhibition of cell shedding from the primary tumor could therefore be exploited to avoid metastasis and delay the progression of the cancer disease. In the present study, we investigated the effects of the polyphenols resveratrol, baicalein, epicatechin, epigallocatechin and polyphenon 60 on cell shedding from… CONTINUE READING

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