Polyphenols downregulate PAI-1 gene expression in cultured human coronary artery endothelial cells: molecular contributor to cardiovascular protection.

@article{Pasten2007PolyphenolsDP,
  title={Polyphenols downregulate PAI-1 gene expression in cultured human coronary artery endothelial cells: molecular contributor to cardiovascular protection.},
  author={Consuelo Pasten and N{\'e}lida C Olave and Lihua Zhou and Edlue M. Tabengwa and Paul E Wolkowicz and Hernan E. Grenett},
  journal={Thrombosis research},
  year={2007},
  volume={121 1},
  pages={59-65}
}
Epidemiologic data have indicated that the intake of polyphenols is inversely associated with mortality from cardiovascular disease. Mitogen-activated protein kinases (MAPKs) are ubiquitous signaling proteins that have been associated with gene regulation. This study determined whether polyphenols (catechin and quercetin) activated kinase-signaling cascades that suppress PAI-1 expression and whether this suppression is at the transcription level in human coronary artery endothelial cells (ECs… CONTINUE READING

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