Polyphenols as Therapeutic Molecules in Alzheimer’s Disease Through Modulating Amyloid Pathways

  title={Polyphenols as Therapeutic Molecules in Alzheimer’s Disease Through Modulating Amyloid Pathways},
  author={Johant Lakey-Beitia and Ruben Berrocal and K. Venkata Subba Rao and Armando A. Durant},
  journal={Molecular Neurobiology},
Alzheimer’s disease (AD) is a complex and multifactorial neurodegenerative condition. The complex pathology of this disease includes oxidative stress, metal deposition, formation of aggregates of amyloid and tau, enhanced immune responses, and disturbances in cholinesterase. Drugs targeted toward reduction of amyloidal load have been discovered, but there is no effective pharmacological treatment for combating the disease so far. Natural products have become an important avenue for drug… CONTINUE READING


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