Polyphenols and health: Moving beyond antioxidants

@article{ChivaBlanch2012PolyphenolsAH,
  title={Polyphenols and health: Moving beyond antioxidants},
  author={Gemma Chiva-Blanch and Francesco Visioli},
  journal={Journal of Berry Research},
  year={2012},
  volume={2},
  pages={63-71}
}
Diets in which plant foods, including berries, provide a relevant portion of caloric intake are associated with a reduced risk of certain degenerative diseases like cancer and atherosclerosis. As known, vegetables and fruits such as berries are rich in polyphenols, which are products of secondary metabolism. In the past few years, research on polyphenols has remarkably expanded and is constantly reporting interesting biological activities of these compounds. Due to the participation of… 

Dietary polyphenols: Structures, bioavailability and protective effects against atherosclerosis.

Strawberry and human health: effects beyond antioxidant activity.

Current information about the potential mechanisms involved in the effects elicited by strawberry polyphenols on human health are reviewed, devoting special attention to the latest findings.

The Health Potential of Fruits and Vegetables Phytochemicals: Notable Examples

D diets rich in fruits and vegetables in combination with medical therapies are being considered as novel approaches to treatment, since some phytochemicals regulate the same genes and pathways targeted by drugs, and might be a promising tool for the prevention and/or amelioration of a wide range of diseases.

The Impact of Dietary Supplementation of Whole Foods and Polyphenols on Atherosclerosis

Not all supplementations work in both male and female animals, suggesting that increasing the variety of foods with different polyphenol compositions may be more effective in mitigating atherosclerosis.

Dietary Polyphenol Supplementation in Food Producing Animals: Effects on the Quality of Derived Products

From this review emerges that polyphenols play an important, though not always clear, role in the quality of meat and meat products, milk and dairy products.

A Review on the Effect of Drying on Antioxidant Potential of Fruits and Vegetables

This review provides an overview of recent findings on the effects of different drying techniques on major antioxidants of fruits and vegetables, in particular, changes in ascorbic acid, carotenoids, flavonoids, phenolic acids, total phenolics, and antioxidant activity.

Diet and Cardiovascular Disease: Effects of Foods and Nutrients in Classical and Emerging Cardiovascular Risk Factors.

Current research places the Mediterranean dietary pattern, rich in fruits and vegetables, as the most cardioprotective, because of its high concentration of bioactive compounds, which exert antioxidant, anti-inflammatory and anti-thrombotic effects contributing to the delay of CVD initiation and progression.

Cell Systems to Investigate the Impact of Polyphenols on Cardiovascular Health

The different cell culture models that have been used so far for polyphenol research in the context of cardiovascular diseases are discussed and the potential of these advanced models to screen for cardiovascular effects of the large pool of bioactive polyphenols present in foods and their metabolites is discussed.

The genetic aspects of berries: from field to health.

This work reviews, on the basis of the in vitro and in vivo evidence, the main berries' phytochemical compounds and their possible mechanisms of action on pathways involved in several type of diseases, with particular attention to cancer, inflammation, neurodegeneration, diabetes and cardiovascular diseases.
...

References

SHOWING 1-10 OF 65 REFERENCES

Polyphenols and cardiovascular disease: a critical summary of the evidence.

This mini-review critically discusses the current limitations of polyphenol research and contends that, in addition to their putative antioxidant action, several biochemical and physiological processes might be influenced by polyphenols.

Flavonoids, vascular function and cardiovascular protection.

Although flavonoid-rich foods and beverages are likely to protect cardiovascular system, further research is needed to characterize the mechanism of action on flavanol-rich Foods, particularly focussing on the lowest effective levels.

Bioavailability and bioefficacy of polyphenols in humans. II. Review of 93 intervention studies.

It is time to rethink the design of in vitro and in vivo studies, so that these issues are carefully considered, and the length of human intervention studies should be increased, to more closely reflect the long-term dietary consumption of polyphenols.

Dietary phenolics: chemistry, bioavailability and effects on health.

This review summarizes the chemistry, biosynthesis and occurrence of the compounds involved, namely the C6-C3-C6 flavonoids-anthocyanins, dihydrochalcones, Flavan-3-ols, flavanones, flavones, Flavonols and isoflavones, and the mechanisms underlying these processes are discussed.

Antioxidant effects of natural bioactive compounds.

An outline of main roles of ROS in biological processes and diseases and how natural bioactive compounds of fruits and vegetables determine their health-promoting properties is presented.

Fruit polyphenols and CVD risk: a review of human intervention studies

There was some evidence to suggest that fruits containing relatively high concentrations of flavonols, anthocyanins and procyanindins, such as pomegranate, purple grapes and berries, were effective at reducing CVD risk factors, particularly with respect to anti-hypertensive effects, but the evidence was limited, inconsistent and often inconclusive.

Nutraceuticals and atherosclerosis: human trials.

A growing body of clinical evidence has demonstrated positive cardiovascular effects associated with dietary fibers, cholesterol-lowering natural agents, olive oil, omega-3 PUFAs, antioxidants, and polyphenols intake, and a need for a better understanding and more scientific evidence of the relative contribution of major nutraceutical constituents to the inhibition of the progression of atherosclerosis and its clinical consequences.

Polyphenols and Human Health: A Prospectus

The recent findings concerning the effects of polyphenols on human health are summarized, the current limitations at pitfalls are analyzed, and future directions for research are proposed.

Metabolic fate of polyphenols in the human superorganism

Bottom-up as well as top-down approaches need to be pursued to link gut microbial diversity to functionality in nutritional phenotypes and, ultimately, to bioactivity of polyphenols.
...