Corpus ID: 51987780

Polyphenols and Neurodegenerative Diseases

  title={Polyphenols and Neurodegenerative Diseases},
  author={Pedro Freitas},
With the expansion of the aged population, the prevalence of age-associated disorders like Alzheimer’s and Parkinson’s disease is growing, as well as the economic burden of its care and treatment. In this light, the preventive and therapeutic benefits of dietary polyphenols may directly improve human life and healthcare costs. Polyphenols display the capacity to protect neurons against oxidative stress, an ability to suppress neuroinflammation, and the potential to promote memory, learning and… Expand
1 Citations
Phenolic characterization and evaluation of the antioxidant and anti-inflammatory properties of Eriocephalus africanus and Geranium robertianum extracts
s in international scientific periodicals with referees Catarino MD, Silva JD, Sobral, AJFN, Cardoso SM (2014). Novel phenolics in Eriocephalus genus. Planta Medica, 80 (16), P1L130. Santos SF,Expand


Benefits from Dietary Polyphenols for Brain Aging and Alzheimer’s Disease
This commentary discusses recent data on effects of curcumin, resveratrol and catechins on Alzheimer’s disease, particularly focusing on results of some epidemiological studies. Expand
Berry fruit supplementation and the aging brain.
The benefits of interventions to retard or reverse age-related neuronal deficits, as well as their subsequent behavioral manifestations, in rodent models are discussed and the putative molecular mechanisms involved in their benefits are described. Expand
Fruit Polyphenols and Their Effects on Neuronal Signaling and Behavior in Senescence
The benefits of interventions in rodent models are discussed and the putative molecular mechanisms involved in their benefits are described, suggesting that interventions may exert protection against age‐related deficits in cognitive and motor function. Expand
Neuroinflammation: modulation by flavonoids and mechanisms of action.
The evidence for flavonoids potential to inhibit neuroinflammation through an attenuation of microglial activation and associated cytokine release, iNOS expression, nitric oxide production and NADPH oxidase activity is highlighted. Expand
Catechin polyphenols: neurodegeneration and neuroprotection in neurodegenerative diseases.
Green tea catechin polyphenols, formerly thought to be simple radical scavengers, are now considered to invoke a spectrum of cellular mechanisms of action related to their neuroprotective activity, including pharmacological activities like iron chelation, scavenging of radicals, activation of survival genes and cell signaling pathways, and regulation of mitochondrial function and possibly of the ubiquitin-proteasome system. Expand
Multifunctional Activities of Green Tea Catechins in Neuroprotection
This review will focus on the multifunctional properties of green tea and its major component (–)-epigallocatechin-3-gallate (EGCG) and their ability to induce neuroprotection and neurorescue in vitro and in vivo and their transitional metal chelating property and inhibition of oxidative stress. Expand
Natural Antioxidants Protect Neurons in Alzheimer’s Disease and Parkinson’s Disease
The author reviews the studies on the protecting effects of natural antioxidants on neurons in neurodegenerative diseases and summarized the results about protective effect of green tea polyphenols on neurons against apoptosis of cellular and animal PD models. Expand
Chemistry and biochemistry of oxidative stress in neurodegenerative disease.
Delineation of the profile of oxidative damage in each disease will provide clues to how the specific neuronal populations are differentially affected by the individual disease conditions. Expand
The neuroprotective potential of flavonoids: a multiplicity of effects
The intense interest in the development of drugs capable of enhancing brain function means that flavonoids may represent important precursor molecules in the quest to develop of a new generation of brain enhancing drugs. Expand
Simultaneous Manipulation of Multiple Brain Targets by Green Tea Catechins: A Potential Neuroprotective Strategy for Alzheimer and Parkinson Diseases
The literature on the impact of the multimodal activities of green tea polyphenols and their neuroprotective effect on AD and PD is reviewed. Expand