Polyphenols activate Nrf2 in astrocytes via H2O2, semiquinones, and quinones.

@article{Erlank2011PolyphenolsAN,
  title={Polyphenols activate Nrf2 in astrocytes via H2O2, semiquinones, and quinones.},
  author={Hilla Erlank and Anat Elmann and Ron Kohen and Joseph Ha Kanner},
  journal={Free radical biology & medicine},
  year={2011},
  volume={51 12},
  pages={
          2319-27
        }
}
Polyphenols, which occur both in edible plants and in foodstuff, have been reported to exert a wide range of health effects; however, the mechanism of action of these molecules is not fully understood. One important cellular pathway affected by polyphenols is the activation of the transcription factor Nrf2 via the electrophile response element, which mediates generation of phase 2 detoxifying enzymes. Our study found that Nrf2 nuclear translocation and the activity of NAD(P)H quinone… CONTINUE READING
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