Polyphenol-stabilized tubular elastin scaffolds for tissue engineered vascular grafts.

@article{Chuang2009PolyphenolstabilizedTE,
  title={Polyphenol-stabilized tubular elastin scaffolds for tissue engineered vascular grafts.},
  author={Ting-Hsien Chuang and Christopher Stabler and Agneta Simionescu and Dan Teodor Simionescu},
  journal={Tissue engineering. Part A},
  year={2009},
  volume={15 10},
  pages={
          2837-51
        }
}
Tissue-engineered vascular grafts require elastic, acellular porous scaffolds with controlled biodegradability and properties matching those of natural arteries. Elastin would be a desirable component for such applications, but elastin does not easily regenerate experimentally. Our approach is to develop tubular elastin scaffolds using decellularization and removal of collagen from porcine carotid arteries ( approximately 5 mm diameter) using alkaline extraction. Because elastin is susceptible… CONTINUE READING
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