Polyphenol-enriched diet prevents coronary endothelial dysfunction by activating the Akt/eNOS pathway.

@article{Vilahur2015PolyphenolenrichedDP,
  title={Polyphenol-enriched diet prevents coronary endothelial dysfunction by activating the Akt/eNOS pathway.},
  author={Gemma Vilahur and Teresa Padro and Laura Casan{\'i} and Guiomar Mendieta and Jose Angel Lopez and Sergio Streitenberger and L Badimon},
  journal={Revista espanola de cardiologia},
  year={2015},
  volume={68 3},
  pages={216-25}
}
INTRODUCTION AND OBJECTIVES The Mediterranean diet, rich in polyphenols, has shown to be cardioprotective. However the mechanisms involved remain unknown. We investigated whether supplementation with a pomegranate extract rich in polyphenols renders beneficial effects on coronary function in a clinically relevant experimental model and characterized the underlying mechanisms. METHODS Pigs were fed a 10-day normocholesterolemic or hypercholesterolemic diet. Half of the animals were given a… CONTINUE READING