Polyphenol associated-DNA adducts in lung and blood mononuclear cells from lung cancer patients.

@article{Vrkonyi2006PolyphenolAA,
  title={Polyphenol associated-DNA adducts in lung and blood mononuclear cells from lung cancer patients.},
  author={Andrea V{\'a}rkonyi and Karl T. Kelsey and Karen Semey and W. J. Bodell and Gy{\"o}rgy L{\'e}vay and Eugen Mark and John C. Wain and David C. Christiani and John K. Wiencke},
  journal={Cancer letters},
  year={2006},
  volume={236 1},
  pages={24-31}
}
The formation of smoking induced-DNA adducts is a critical factor in the induction of human lung cancer. As derivates of benzene and polyaromatic hydrocarbons (PAHs) are important compounds of tobacco smoke, in DNA isolated from human lung and blood mononuclear cells (MNCs) from 38 lung cancer patients, we used the (32)P-postlabeling assay to detect polyphenol associated DNA adducts. Two DNA adducts were detected in blood MNCs and lung tissue that co-chromatographed with DNA modifications from… CONTINUE READING