Polyphenol‐rich virgin olive oil reduces insulin resistance and liver inflammation and improves mitochondrial dysfunction in high‐fat diet fed rats

@article{Lama2017PolyphenolrichVO,
  title={Polyphenol‐rich virgin olive oil reduces insulin resistance and liver inflammation and improves mitochondrial dysfunction in high‐fat diet fed rats},
  author={Adriano Lama and Claudio Pirozzi and Mariano Mollica and Giovanna Trinchese and Francesca Di Guida and G. Cavaliere and Antonio Calignano and Giuseppina Mattace Raso and Roberto Berni Canani and Rosaria Meli},
  journal={Molecular Nutrition \& Food Research},
  year={2017},
  volume={61},
  pages={1600418}
}
Scope: Virgin olive oil is an essential component of the Mediterranean diet. Its antioxidant and anti‐inflammatory properties are mainly linked to phenolic contents. This study aims to evaluate the beneficial effects of a polyphenol‐rich virgin olive oil (HPCOO) or olive oil without polyphenols (WPOO) in rats fed high‐fat diet (HFD). Methods and results: Male Sprague‐Dawley rats were divided into four groups based on the different types of diet: (I) standard diet (STD); (II) HFD; (III) HFD… Expand
Supplementation with Docosahexaenoic Acid and Extra Virgin Olive Oil Prevents Liver Steatosis Induced by a High-Fat Diet in Mice through PPAR-α and Nrf2 Upregulation with Concomitant SREBP-1c and NF-kB Downregulation.
TLDR
DHA + EVOO supplementation significantly reduces hepatic steatosis, oxidative stress, systemic inflammation, and insulin resistance and is associated with the activation/inactivation of key transcription factors involved in the above-mentioned processes. Expand
Hydroxytyrosol supplementation ameliorates the metabolic disturbances in white adipose tissue from mice fed a high-fat diet through recovery of transcription factors Nrf2, SREBP-1c, PPAR-γ and NF-κB.
BACKGROUND White adipose tissue (WAT) have a relevant metabolic and inflammatory function, in overweight or obesity conditions. In this regard, the WAT under over feeding nutrition present aExpand
High-fat but not normal-fat intake of extra virgin olive oil modulates the liver proteome of mice
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The data indicate that the intake of the HO diet induced hepatic adjustments, which were partially successful in counteracting the detrimental outcomes of a high-fat feeding, which had beneficial effects which were not accompanied by significant modifications on hepatic proteome. Expand
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The present narrative review focuses on phenols, part of red wine and virgin olive oil, discussing the evidence of their effects on lipids, blood pressure, atheromatous plaque and glucose metabolism. Expand
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Dietary CP supplementation reduces body weight and improves insulin resistance in high-fat diet (HFD)-fed mice in a dose-dependent manner and modulates the composition in HFD-fed mice, suggesting that male mice were more sensitive to CP treatment than female mice. Expand
Phytol increases adipocyte number and glucose tolerance through activation of PI3K/Akt signaling pathway in mice fed high-fat and high-fructose diet.
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Phytol increased adipocyte number in iWAT and improved glucose tolerance in mice fed HFFD, which was coincident with the enhanced adipogenesis and glucose uptake in 3T3-L1, and was associated with activation of PI3K/Akt signaling pathway. Expand
Palmitoylethanolamide counteracts hepatic metabolic inflexibility modulating mitochondrial function and efficiency in diet‐induced obese mice
  • C. Annunziata, A. Lama, +13 authors R. Meli
  • Chemistry, Medicine
  • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2020
TLDR
Findings identify PEA as a modulator of hepatic lipid and glucose homeostasis, limiting metabolic inflexibility induced by nutrient overload, as well as a pivotal role of AMPK in PEA‐induced adaptive metabolic setting. Expand
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