Polypeptide chain termination in vitro: isolation of a release factor.

  title={Polypeptide chain termination in vitro: isolation of a release factor.},
  author={Mario R Capecchi},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={58 3},
  • Mario R Capecchi
  • Published 1967 in
    Proceedings of the National Academy of Sciences…
The growing polypeptide chain remains bound to the ribosome-messenger RNA complex through the sRNA carrying the last amino acid incorporated into the polypeptide chain.' On completion of the polypeptide chain a mechanism must exist for releasing it from the protein-synthesizing machinery. To date, most of the effort has been concentrated on establishing the coded information required for this event.2-5 Very little is known about the biochemical mechanism of releasing the finished protein. The… CONTINUE READING


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