Polyoxypregnane steroids with an open-chain sugar moiety from Marsdenia tenacissima and their chemoresistance reversal activity.

@article{Yao2016PolyoxypregnaneSW,
  title={Polyoxypregnane steroids with an open-chain sugar moiety from Marsdenia tenacissima and their chemoresistance reversal activity.},
  author={Sheng Yao and Kenneth Kin-wah To and Liang Ma and Chun Yin and Chunping Tang and Stella Chai and Chang-qiang Ke and Ge Lin and Yang Ye},
  journal={Phytochemistry},
  year={2016},
  volume={126},
  pages={
          47-58
        }
}
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Screening potential antagonists of epidermal growth factor receptor from Marsdenia tenacissima via cell membrane chromatography model assisted by HPLC-ESI-IT-TOF-MS.
TLDR
The MTT assay demonstrated that gefitinib and TS (especially TI) could inhibit the growth of EGFR highly expressed cell lines in a dose-dependent manner in the range of 5-50 μmol/L.
Sesquiterpenoids and triterpenoids from Secamone lanceolata blume with inhibitory effects on nitric oxide production.
Reversal of multidrug resistance by Marsdenia tenacissima and its main active ingredients polyoxypregnanes.
  • K. To, Xu Wu, G. Lin
  • Biology, Medicine
    Journal of ethnopharmacology
  • 2017
Polyoxypregnanes as safe, potent, and specific ABCB1-inhibitory pro-drugs to overcome multidrug resistance in cancer chemotherapy in vitro and in vivo
Distributions of eight bioactive components in rat tissues administered with Marsdenia tenacissima extract orally detected through UPLC-MS/MS.
TLDR
A new scientific ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) approach was constructed to simultaneously quantify the contents of Tenacissosides B, G, H, I, cryptochlorogenic acid, chlorogenic acid and caffeic acid in rats administered with M. tenacissima extract orally and showed rapid distribution within all the tested tissues.
Marsdenia tenacissima: A Review of Traditional Uses, Phytochemistry and Pharmacology.
TLDR
The present review aimed to achieve a comprehensive and up-to-date investigation in ethnopharmacology, phytochemistry, pharmacology, clinical study, pharmacokinetics, toxicology and quality control of Marsdenia tenacissima.
Adduct ion‐targeted qualitative and quantitative analysis of polyoxypregnanes by ultra‐high pressure liquid chromatography coupled with triple quadrupole mass spectrometry
Jianpi-Huayu Formula Inhibits Development of Hepatocellular Carcinoma by Regulating Expression of miR-602, Which Targets the RASSF1A Gene
TLDR
Results indicated that JPHY could potentially be used to treat HCC by targeting miR-602, which targets the RASSF1A gene, which in turn plays a major role in HCC pathogenesis.
The Antitumor Activities of Marsdenia tenacissima
TLDR
Marsdenia tenacissima, a traditional Chinese herbal medicine, has long been used for thousands of years to treat asthma, tracheitis, rheumatism, etc and can inhibit different cancer types including non-small cell lung cancer, malignant tumors, hepatic carcinoma, and so on.
A homologues prediction strategy for comprehensive screening and characterization of C21 steroids from Xiao‐ai‐ping injection by using ultra high performance liquid chromatography coupled with high resolution hybrid quadrupole‐orbitrap mass spectrometry
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Polyoxypregnanes from Marsdenia tenacissima
Five glycosides from the chinese drug ‘tong-guang-san’: The stems of marsdenia tenacissima☆
A new C21 steroid glycoside from Marsdenia tenacissima
Three New Polyoxypregnane Glycosides from Marsdenia tenacissima
Three new polyoxypregnane glycosides, marsdenosides I–K (1–3), were isolated from the stem of Marsdenia tenacissima. The structures were elucidated on the basis of in-depth spectroscopic analyses,…
Oligosaccharides from Hoya carnosa.
Oligosaccharides A, B, and C (1-3, respectively) were isolated from the stem of Hoya carnosa. Their structures were established by NMR and chemical methods. Compounds 1 and 2 were…
Constituents of Chinese Crude Drug "Wujiapi."VVIII. On the Structures of New Oligosaccharides C1, D2, F1 and F2 of Bei-Wujiapi
Four new type oligosaccharides C1, D2, F1 and F2 of Bei-Wujiapi (cortex of Periploca sepium BGE.) were elucidated to be 2-O-acetyl-β-D-digitalopyranosyl (1→4)-β-D-cymaropyranosyl…
Marsdenosides A-H, polyoxypregnane glycosides from Marsdenia tenacissima.
Two New C21 Steroids from Marsdenia tenacissima
Two new C21 steroids were isolated from the CHCl3 extract of the stem of Marsdenia tenacissima. On the basis of spectroscopic analysis and chemical methods, their structures were elucidated as…
Polyoxypregnane steroids from the stems of Marsdenia tenacissima.
A new polyoxypregnane aglycone, tenacigenin D (1), and seven new C21 steroid glycosides, tenacissimosides D-J (2-8), were isolated from the stems of Marsdenia tenacissima. Their structures were…
Tenacigenin B derivatives reverse P-glycoprotein-mediated multidrug resistance inHepG2/Dox cells.
TLDR
A preliminary mechanistic study has suggested that 1 might modulate P-glycoprotein-mediated multidrug resistance through directly interacting with the Pgp substrate site.
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