Polyoxazoline-peptide adducts that retain antibody avidity.

  title={Polyoxazoline-peptide adducts that retain antibody avidity.},
  author={William H. Velander and R D Madurawe and Anuradha Subramanian and G. G. Naveen Kumar and G Sinai-Zingde and J S Riffle and C L Orthner},
  journal={Biotechnology and bioengineering},
  volume={39 10},
Synthetic polymers have long been used to modify various properties of proteins such as activity and solubility. Polyethylene glycol (PEG) has been widely used to form adducts with enzymes and antibodies. In this study, the polyoxazoline family of water-soluble polymers was used to synthesize adducts containing a synthetic peptide recognized by a monoclonal… CONTINUE READING