Polyostotic fibrous dysplasia with contrasting responses to calcitonin and mithramycin: Aetiological and therapeutic implications

@article{Long1988PolyostoticFD,
  title={Polyostotic fibrous dysplasia with contrasting responses to calcitonin and mithramycin: Aetiological and therapeutic implications},
  author={A. Long and T. Loughlin and R. Towers and T. McKenna},
  journal={Irish Journal of Medical Science},
  year={1988},
  volume={157},
  pages={229-234}
}
  • A. Long, T. Loughlin, +1 author T. McKenna
  • Published 1988
  • Medicine
  • Irish Journal of Medical Science
  • SummaryTREATMENT of a patient with symptomatic progressive fibrous dysplasia offered an opportunity to examine the effectiveness of agents known to influence bone turnover, in modifying the activity of the disorder. In response to calcitonin markedly elevated urinary hydroxyproline excretion was unaltered although serum alkaline phosphatase tended to fall. However, the urinary calcium excretion more than doubled. In contrast, the introduction of intravenous mithramycin, brought about a… CONTINUE READING
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