Polyomavirus tumor induction in mice: effects of polymorphisms of VP1 and large T antigen.

@article{Freund1991PolyomavirusTI,
  title={Polyomavirus tumor induction in mice: effects of polymorphisms of VP1 and large T antigen.},
  author={Robert Freund and Angelino Calderone and Clyde J. Dawe and Thomas L. Benjamin},
  journal={Journal of virology},
  year={1991},
  volume={65 1},
  pages={335-41}
}
By testing recombinants between "high tumor" (inducing a high incidence of tumors) and "low tumor" (inducing a low incidence of tumors) strains of polyomavirus, we have previously shown that the key determinant(s) for induction of a high tumor profile resides in coding regions of the high tumor strain (R. Freund, G. Mandel, G. G. Carmichael, J. P. Barncastle, C. J. Dawe, and T. L. Benjamin, J. Virol. 61:2232-2239, 1987). Three single-amino-acid differences between the PTA (high tumor) and RA… CONTINUE READING

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