Polyomavirus persistence in lymphocytes: prevalence in lymphocytes from blood donors and healthy personnel of a blood transfusion centre.

@article{Dolei2000PolyomavirusPI,
  title={Polyomavirus persistence in lymphocytes: prevalence in lymphocytes from blood donors and healthy personnel of a blood transfusion centre.},
  author={Antonina Dolei and Vincenzo Pietropaolo and Eliane Solar Gomes and C Di Taranto and Maria Ziccheddu and Michelina Spanu and Claudio Lavorino and Marco Manca and Anna Marta Degener},
  journal={The Journal of general virology},
  year={2000},
  volume={81 Pt 8},
  pages={1967-73}
}
BK and JC polyomaviruses (BKV and JCV) are widespread in humans and are thought to persist and reactivate under immune alterations. In addition to the kidney, lymphoid cells have been proposed as a site of latency. However, while this was shown to occur in immunocompromised patients, discordant data were published for healthy humans. To help to solve this issue, an extensive study (231 healthy subjects) was carried out on peripheral blood mononuclear cells (PBMC) from blood donors of two towns… CONTINUE READING

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