Polyomavirus-induced malignant transformation: comparative analysis of wild type and mutant middle T-overexpressing cell lines.

@article{Armelin1996PolyomavirusinducedMT,
  title={Polyomavirus-induced malignant transformation: comparative analysis of wild type and mutant middle T-overexpressing cell lines.},
  author={M. C. S. Armelin and M. S. Oliveira},
  journal={Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas},
  year={1996},
  volume={29 9},
  pages={1133-40}
}
Polyomavirus, a DNA tumor virus, expresses three viral oncoproteins (large, middle and small T antigens), causes malignant transformation in cell culture and induces multiple tumors in vivo. The middle T (MT) antigen seems to play an essential role in transformation and tumorigenicity. The observation that MT-overexpressing cell lines are able to grow in… CONTINUE READING