Polyoma tumorigenesis in mice: evidence for dominant resistance and dominant susceptibility genes of the host.

@article{Freund1992PolyomaTI,
  title={Polyoma tumorigenesis in mice: evidence for dominant resistance and dominant susceptibility genes of the host.},
  author={Robert Michael Freund and Thomas W Dubensky and Roderick Terry Bronson and Andrey Sotnikov and John Phillip Carroll and Thomas Livingston Benjamin},
  journal={Virology},
  year={1992},
  volume={191 2},
  pages={
          724-31
        }
}
We have determined the tumor responses of nine inbred mouse strains and of two F1 hybrids following inoculation with polyoma virus. The results showed wide variations in the frequencies of mice developing tumors. Correlation with H-2 haplotype were evident. C3H/BiDa mice of H-2k type were fully susceptible, while C57BL/6 mice of H-2b type were completely resistant. DBA/2 and BALB/c mice, both H-2d, were of low susceptibility. Contributions of the major histocompatibility complex were… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 24 CITATIONS

Similar Papers

Loading similar papers…