Polyoma small T antigen triggers cell death via mitotic catastrophe

  title={Polyoma small T antigen triggers cell death via mitotic catastrophe},
  author={Arun T. Pores Fernando and Shaida Andrabi and Onur Cizmecioglu and Cailei Zhu and David M. Livingston and Jonathan M. G. Higgins and Brian S. Schaffhausen and Thomas M Roberts},
Polyoma small T antigen (PyST), an early gene product of the polyoma virus, has been shown to cause cell death in a number of mammalian cells in a protein phosphatase 2A (PP2A)-dependent manner. In the current study, using a cell line featuring regulated expression of PyST, we found that PyST arrests cells in mitosis. Live-cell and immunofluorescence studies showed that the majority of the PyST expressing cells were arrested in prometaphase with almost no cells progressing beyond metaphase… CONTINUE READING
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